This website supports the research project ‘Traceability for biologically relevant molecules and entities’, known as ‘BioSITrace’. The project is run in collaboration with European National Measurement Institutes, industry and academia and is funded by the European Metrology Research Programme.
Accurate counting of biological entities underpins many sectors including healthcare, security, environment, biotechnology, and food. Examples include viral load monitoring in patients, circulating tumour cells in cancer, presence of GMOs, allergens and pathogens in foods, host cell contamination in vaccines and biopharmaceuticals, QC of tissue engineered products etc. These biomeasurements lend themselves to description in terms of number of discrete entities such as DNA copies or number of cells. However, a lack of higher order reference methods and materials is a major hindrance for deriving traceability and measurement comparability, and impacts upon accreditation and regulatory compliance.
BioSITrace aims to improve the state of the art in two key techniques for providing higher order traceability in biological measurement: the application of purified calibration materials and the use of enumeration technologies.