The project

Accurate counting of biological entities underpins many sectors including healthcare, security, environment, biotechnology, and food. For example, viral load monitoring in patients, circulating tumour cells in cancer or presence of GMOs, lend themselves to description in terms of number of discrete entities such as DNA copies or number of cells. There is, however, a lack of higher order reference methods and materials to facilitate traceability and measurement comparability which impacts upon accreditation and regulatory compliance.

The BioSITrace project aims to improve the state of the art in two key techniques for providing higher order traceability in biological measurement: the application of purified calibration materials and the use of enumeration technologies.

BioSITrace will develop methods and protocols for metrologically sound characterisation of pure biological materials for calibration. It will develop new counting approaches including methods of verification that permit their use as reference methods. This will provide the basis for a substantial increase in the range of biological measurements that can rely on traceability to the SI.